Mechanosensitive ion channels push cancer progression
| Autor: | Albrecht Schwab, Zoltán Pethő, Karolina Najder, Etmar Bulk |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Carcinogenesis Physiology Mechanotransduction Cellular Ion Channels Extracellular matrix 03 medical and health sciences Transient receptor potential channel 0302 clinical medicine Neoplasms Tumor Microenvironment Animals Humans Calcium Signaling Mechanotransduction Molecular Biology Ion channel Calcium signaling Mechanosensation Chemistry Cell migration Cell Biology Cell biology Gene Expression Regulation Neoplastic 030104 developmental biology Tumor Escape Mechanosensitive channels 030217 neurology & neurosurgery |
| Zdroj: | Cell Calcium. 80:79-90 |
| ISSN: | 0143-4160 |
| DOI: | 10.1016/j.ceca.2019.03.007 |
| Popis: | In many cases, the mechanical properties of a tumor are different from those of the host tissue. Mechanical cues regulate cancer development by affecting both tumor cells and their microenvironment, by altering cell migration, proliferation, extracellular matrix remodeling and metastatic spread. Cancer cells sense mechanical stimuli such as tissue stiffness, shear stress, tissue pressure of the extracellular space (outside-in mechanosensation). These mechanical cues are transduced into a cellular response (e. g. cell migration and proliferation; inside-in mechanotransduction) or to a response affecting the microenvironment (e. g. inducing a fibrosis or building up growth-induced pressure; inside-out mechanotransduction). These processes heavily rely on mechanosensitive membrane proteins, prominently ion channels. Mechanosensitive ion channels are involved in the Ca2+-signaling of the tumor and stroma cells, both directly, by mediating Ca2+ influx (e. g. Piezo and TRP channels), or indirectly, by maintaining the electrochemical gradient necessary for Ca2+ influx (e. g. K2P, KCa channels). This review aims to discuss the diverse roles of mechanosenstive ion channels in cancer progression, especially those involved in Ca2+-signaling, by pinpointing their functional relevance in tumor pathophysiology. |
| Databáze: | OpenAIRE |
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