Prevalence and 20-year epidemiological trends of glomerular diseases in the adult Saudi population: a multicenter study
| Autor: | Hanadi Alhozali, Hala Kfoury, Khaled O. Alsaad, Noura Al Oudah, Lamees I Al-mezaini, Sufia Husain, Abdulkareem Alsuwaida, Ghadeer A Mokhtar, Abdulrahaman Alabdulsalam, Junaid J. Wadera, Talal AlFaadhel, Rehan Ahmed Siddiqui, Feras A. Alsuwaida, Ammar Bakheet, Majed M Alanazi, Mahmoud Yassin AlHamad, Mohamed Kechrid, Ashraf Abdelrehman, Noura Ahmed |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Adolescent Biopsy Population Saudi Arabia MEDLINE lcsh:Medicine 030209 endocrinology & metabolism Young Adult 03 medical and health sciences 0302 clinical medicine Epidemiology Prevalence medicine Humans Diabetic Nephropathies 030212 general & internal medicine Young adult education Aged Retrospective Studies education.field_of_study Glomerulosclerosis Focal Segmental business.industry Incidence Incidence (epidemiology) lcsh:R Glomerulosclerosis Glomerulonephritis IGA Glomerulonephritis Retrospective cohort study General Medicine Middle Aged medicine.disease Lupus Nephritis Original Article Female Kidney Diseases sense organs business |
| Zdroj: | Annals of Saudi Medicine, Vol 39, Iss 3, Pp 155-161 (2019) Annals of Saudi Medicine |
| ISSN: | 0975-4466 0256-4947 |
| DOI: | 10.5144/0256-4947.2019.155 |
| Popis: | BACKGROUND: Recent international reports have shown significant changes in the incidence of different glomerular diseases. OBJECTIVE: Examine temporal and demographic trends of biopsy-diagnosed glomerular diseases in the adult population of Saudi Arabia over the last two decades. DESIGN: Medical record review. SETTINGS: Four tertiary medical centers in Saudi Arabia. PATIENTS AND METHODS: We identified all patients that underwent native kidney biopsy between 1998 and 2017. MAIN OUTCOME MEASURES: The frequency and the disease trends in four biopsy eras (1998–2002, 2003–2007, 2008–2011, and 2012–2017) for different glomerular diseases. SAMPLE SIZE AND CHARACTERISTICS: 1070 patients, 18-65 years of age; 54.1% female. RESULTS: Of 1760 patients who underwent native kidney biopsies, 1070 met inclusion criteria. Focal segmental glomerulosclerosis was the most common biopsy-diagnosed disease, with comparable frequencies over the four eras (23.6%, 19.8%, 24.1%, and 17.1, respectively [P value for trend=.07]). The frequency of immunoglobulin A nephropathy increased progressively. The incidence of membranoproliferative glomerulonephritis declined significantly. Among the secondary types of glomerular diseases, systemic lupus erythematosus-associated lupus nephritis was the most common, followed by diabetic nephropathy. The prevalence of diabetic nephropathy increased from 1.4% in the first era to 10.2% in the last one. CONCLUSIONS: Trends in biopsy-diagnosed glomerular disease have changed. While focal segmental glomerulosclerosis remains the most common glomerular disease, there has been a significant rise in the prevalence of immunoglobulin A nephropathy and diabetic nephropathy. In contrast, membranoproliferative glomerulonephritis has declined. LIMITATIONS: Retrospective methodologies are vulnerable to lost data. CONFLICT OF INTEREST: None. |
| Databáze: | OpenAIRE |
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