Serum Hepcidin and Iron Absorption in Paediatric Inflammatory Bowel Disease
| Autor: | Francesca Rossi, Natascia Campostrini, A. Alessandrella, Silverio Perrotta, Renata Auricchio, Annamaria Staiano, Bruno Nobili, Massimo Martinelli, Caterina Strisciuglio, Erasmo Miele, Domenico Girelli |
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| Přispěvatelé: | Martinelli, Massimo, Strisciuglio, Caterina, Alessandrella, Annalisa, Rossi, Francesca, Auricchio, Renata, Campostrini, Natascia, Girelli, Domenico, Nobili, Bruno, Staiano, Annamaria, Perrotta, Silverio, Miele, Erasmo |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty hepcidin IBD Iron Absorption Iron Absorption Adolescent Iron IBD Severity of Illness Index Gastroenterology Inflammatory bowel disease 03 medical and health sciences 0302 clinical medicine Crohn Disease Hepcidins Hepcidin Internal medicine Humans Medicine Prospective Studies Child Prospective cohort study Anemia Iron-Deficiency biology medicine.diagnostic_test business.industry Case-control study General Medicine medicine.disease Ferritin Celiac Disease Cross-Sectional Studies Logistic Models Case-Control Studies Child Preschool 030220 oncology & carcinogenesis Erythrocyte sedimentation rate Ferritins Immunology biology.protein Erythropoiesis Original Article Colitis Ulcerative Female 030211 gastroenterology & hepatology hepcidin Calprotectin business Biomarkers |
| Zdroj: | Journal of Crohn's and Colitis. 10:566-574 |
| ISSN: | 1876-4479 1873-9946 |
| Popis: | We sought to correlate hepcidin levels in inflammatory bowel disease [IBD] children with disease activity, inflammatory markers, and iron load test [ILT] and to compare IBD patients with coeliac and healthy patients.Between December 2012 and June 2013, 145 subjects [50 IBD patients, 45 coeliac patients and 50 healthy controls] were included in the study. All patients underwent the following examinations: blood count, iron status, erythropoiesis parameters, serum hepcidin, C-reactive protein [CRP], and erythrocyte sedimentation rate [ESR]. In order to evaluate the efficacy of iron absorption, ILT was performed in IBD patients. Disease activity indexes and IBD duration, localisation, and therapy were also evaluated, and a faecal sample for calprotectin collected.Serum hepcidin was significantly higher in IBD patients with active disease compared with both coeliac and healthy patients [p = 0.005, p = 0.003 respectively]. In a multivariate logistic regression model, having a Paediatric Crohn's Disease Activity Index [PCDAI] / Paediatric Ulcerative Colitis Activity Index [PUCAI] ≥ 30 resulted in the only variable independently associated with a positive serum hepcidin (odds ratio [OR] = 6.87; 95% confidence interval [CI] 1.4-33, p = 0.01]]. Patients with iron malabsorption [IM] showed higher values of ESR, CRP, and hepcidin [p = 0.02, p = 0.001, and p = 0.06, respectively]. Eight out of 12 [66.7%] children with IM showed an active disease compared with 6/31 [19.3%] children with normal ILT [p = 0.01]. Hepcidin levels correlated negatively with ILT [r = -0.451, p = 0.002], and positively with ferritin and CRP [r = 0.442, p = 0.0001; r = 0.243, p = 0.009, respectively]Our study demonstrates that serum hepcidin is increased in IBD children with active disease and it is responsible for IM. |
| Databáze: | OpenAIRE |
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