Pattern of brain injury and depressed heart rate variability in newborns with hypoxic ischemic encephalopathy
| Autor: | An N. Massaro, Gilbert Vezina, Adre J. du Plessis, Marina Metzler, Nickie Andescavage, Yunfei Wang, Rathinaswamy B. Govindan, Tareq Al-Shargabi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Article Hypoxic Ischemic Encephalopathy 03 medical and health sciences 0302 clinical medicine Text mining Heart Rate 030225 pediatrics Internal medicine Heart rate Basal ganglia medicine Humans Heart rate variability Depression (differential diagnoses) medicine.diagnostic_test business.industry Infant Newborn White Matter Injury Magnetic resonance imaging 3. Good health Anesthesia Hypoxia-Ischemia Brain Pediatrics Perinatology and Child Health Cardiology Female business 030217 neurology & neurosurgery |
| Zdroj: | Pediatric research |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1038/pr.2017.94 |
| Popis: | BackgroundDecreased heart rate variability (HRV) is a measure of autonomic dysfunction and brain injury in newborns with hypoxic ischemic encephalopathy (HIE). This study aimed to characterize the relationship between HRV and brain injury pattern using magnetic resonance imaging (MRI) in newborns with HIE undergoing therapeutic hypothermia.MethodsHRV metrics were quantified in the time domain (αS, αL, and root mean square at short (RMSS) and long (RMSL) timescales) and frequency domain (relative low-(LF) and high-frequency (HF) power) over 24-27 h of life. The brain injury pattern shown by MRI was classified as no injury, pure cortical/white matter injury, mixed watershed/mild basal ganglia injury, predominant basal ganglia or global injury, and death. HRV metrics were compared across brain injury pattern groups using a random-effects mixed model.ResultsData from 74 infants were analyzed. Brain injury pattern was significantly associated with the degree of HRV suppression. Specifically, negative associations were observed between the pattern of brain injury and RMSS (estimate -0.224, SE 0.082, P=0.006), RMSL (estimate -0.189, SE 0.082, P=0.021), and LF power (estimate -0.044, SE 0.016, P=0.006).ConclusionDegree of HRV depression is related to the pattern of brain injury. HRV monitoring may provide insights into the pattern of brain injury at the bedside. |
| Databáze: | OpenAIRE |
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