Low-dose aspirin does not improve ovarian responsiveness or pregnancy rate in IVF and ICSI patients: a randomized, placebo-controlled double-blind study
| Autor: | K. Mäkikallio, Maritta Hippeläinen, Hannu Martikainen, Helena Tinkanen, M. Päkkilä, Seppo Heinonen, Juha Rasanen, Leena Tuomivaara, J.S. Tapanainen |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Pregnancy test medicine.medical_specialty Pregnancy Rate medicine.medical_treatment Fertilization in Vitro Placebo Placebos Double-Blind Method Ovulation Induction Pregnancy medicine Humans Cyclooxygenase Inhibitors Prospective Studies Sperm Injections Intracytoplasmic Treatment Failure Gynecology Aspirin business.industry Ovary Rehabilitation Obstetrics and Gynecology medicine.disease Embryo transfer Pregnancy rate Reproductive Medicine Negative Pregnancy Test Gestation Female Ovulation induction business Infertility Female |
| Zdroj: | Human Reproduction. 20:2211-2214 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/dei020 |
| Popis: | BACKGROUND: Poor ovarian and endometrial responses to gonadotrophin stimulation in assisted reproduction techniques lead to decreased pregnancy rates. The aim of the present study was to test the hypothesis that low-dose aspirin started prior to controlled ovarian stimulation improves ovarian responsiveness, pregnancy rate (PR) and pregnancy outcome. METHODS: A total of 374 women who were to undergo IVF/ICSI were randomized to receive 100 mg of aspirin (n = 186) or placebo (n = 188) daily. Treatment was started on the first day of controlled ovarian stimulation. It was continued until menstruation or a negative pregnancy test. Pregnant women continued the medication until delivery. The main outcome measures were the number of oocytes, number and quality of embryos, the clinical PR and pregnancy outcome. RESULTS: The mean (± SD) number of oocytes (12.0 ± 7.0 versus 12.7 ± 7.2), the total mean number of embryos (5.82 ± 4.35 versus 5.99 ± 4.66), the mean number of top quality embryos (0.99 ± 1.39 versus 1.18 ± 1.51) and the number of embryos transferred (1.64 ± 0.64 versus 1.63 ± 0.71) did not differ in the aspirin and placebo groups. Between the aspirin and placebo group, there was no statistically significant difference in clinical PR per embryo transfer (25.3%, n = 44 out of 174 versus 27.4%, n = 48 out of 175) or clinical PR per cycle initiated (23.7% versus 25.5%). Birth rate per embryo transfer did not differ significantly between the aspirin (18.4%) and placebo (21.1%) groups. The incidence of poor responders [12 (6.5%) versus 13 (6.9%)] was similar in both groups. CONCLUSIONS: The present results indicate that low-dose aspirin treatment does not have any beneficial effect on ovarian responsiveness, PR and pregnancy outcome in unselected women undergoing IVF/ICSI. |
| Databáze: | OpenAIRE |
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