Topoisomerase IIα Expression as an Independent Prognostic Factor in Hodgkin's Lymphoma
| Autor: | Marie-Christine Kyrtsonis, Penelope Korkolopoulou, Maria K. Angelopoulou, Christos Kittas, Evangelia M. Dimitriadou, Christina Kalpadakis, Styliani I. Kokoris, Marina Matzouranis, I Thymara, Loukas Kaklamanis, Gerassimos A. Pangalis, Efstratios Patsouris, Panayiotis Panayiotidis, Ipatia Doussis-Anagnostopoulou, Theodoros P. Vassilakopoulos, Athina Androulaki, Marina P. Siakantaris |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Oncology Cancer Research Pathology medicine.medical_specialty Adolescent Disease-Free Survival Antigens Neoplasm Predictive Value of Tests Recurrence Interquartile range Internal medicine Biomarkers Tumor medicine Humans Aged Aged 80 and over biology business.industry Topoisomerase Remission Induction Cancer Middle Aged Prognosis medicine.disease Hodgkin's lymphoma Hodgkin Disease Lymphoma DNA-Binding Proteins DNA Topoisomerases Type II Ki-67 Antigen ABVD Quartile Multivariate Analysis Disease Progression biology.protein Immunohistochemistry Female business medicine.drug |
| Zdroj: | Clinical Cancer Research. 14:1759-1766 |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-07-1395 |
| Popis: | Purpose: To correlate the immunohistochemical expression of topoisomerase IIα (topoIIα) in Hodgkin's lymphoma (HL) with clinicopathological parameters, the expression of Ki-67 and the outcome of patients, who had been homogenously treated with ABVD or equivalent regimens. Experimental Design: Immunohistochemistry using the monoclonal antibody Ki-S1 (topoIIα) was performed in 238 HL patients. MiB1 (Ki-67) expression was evaluated in 211/238. Results: The mean ± SD percentage of topoIIα- and Ki-67–positive Hodgkin-Reed-Sternberg (HRS) cells was 63 ± 19% (5%-98%) and 73 ± 19% (8%-99%), respectively. The median percentage of topoIIα-positive HRS cells was 64% (interquartile range, 51-78%). There was no correlation between topoIIα expression and patient characteristics. TopoIIα and Ki-67 expression were correlated (Spearman's Rho 0.255, P < 0.001). TopoIlα expression within the highest quartile of this patient population was predictive of failure free survival (FFS) (10-year rates 82 ± 3% vs 68 ± 7%, P = 0.02 for patients falling into the quartiles 1-3 and 4 respectively). In multivariate analysis topoIIα expression was independently predictive of FFS. Conclusion: TopoIIα was expressed in all cases of HL showing a correlation with Ki-67 expression. Under current standard therapy including drugs inhibiting its activity, topoIIα was an independent adverse predictor of FFS with no statistically significant correlation with other established prognostic factors. |
| Databáze: | OpenAIRE |
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