Preoperative predictors of pathological lymph node metastasis in patients with renal cell carcinoma undergoing retroperitoneal lymph node dissection
| Autor: | Kara N. Babaian, Dae Y. Kim, Patrick A. Kenney, Christopher G. Wood, Joseph Wong, Christopher Sanchez, Justin E. Fang, Jonathan A. Gerber, Adin Didic, Adelani Wahab, Vishnukamal Golla, Cristina Torres, Pheroze Tamboli, Wei Qiao, Surena F. Matin, Jose A. Karam |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Urology medicine.medical_treatment Retroperitoneal Lymph Node Retroperitoneal lymph node dissection Young Adult Renal cell carcinoma Carcinoma medicine Humans Retroperitoneal Space Lymph node Carcinoma Renal Cell Aged Retrospective Studies Aged 80 and over business.industry Cancer Middle Aged medicine.disease Prognosis Nephrectomy Kidney Neoplasms Surgery Nomograms medicine.anatomical_structure Lymphatic Metastasis Preoperative Period Lymph Node Excision Female Radiology Lymph business |
| Zdroj: | The Journal of urology. 193(4) |
| ISSN: | 1527-3792 |
| Popis: | Patients with locally advanced renal cell carcinoma represent a subset that may benefit from retroperitoneal lymph node dissection. We identified preoperative clinical predictors of positive lymph nodes in patients with renal cell carcinoma without distant metastasis who underwent retroperitoneal lymph node dissection.We retrospectively analyzed data on a consecutive cohort of 1,270 patients with cTany Nany M0 renal cell carcinoma who were treated at a single institution from 1993 to 2012. Multivariate analysis was performed to determine preoperative predictors of pathologically positive lymph nodes in patients who underwent retroperitoneal lymph node dissection. A nomogram was developed to predict the probability of lymph node metastasis. Overall, cancer specific and recurrence-free survival was estimated using the Kaplan-Meier Method.We identified 1,270 patients with renal cell carcinoma without distant metastasis who had (564) or did not have (706) retroperitoneal lymph node dissection performed. Of the 564 patients 131 (23%) and 433 (77%) had pN1 and pN0 disease, and 60 (37%) and 29 (7.2%) had cN1pN0 and cN0pN1 disease, respectively. ECOG PS, cN stage, local symptoms and lactate dehydrogenase were associated with nodal metastasis on multivariable analysis. A nomogram was developed with a C-index of 0.89 that demonstrated excellent calibration. Differences in overall, cancer specific and recurrence-free survival among pNx, pN0 and pN1 cases were statistically significant (p0.001).Local symptoms, ECOG PS, cN stage and lactate dehydrogenase were independent predictors of lymph node metastasis in patients who underwent retroperitoneal lymph node dissection. Our predictive nomogram using these factors showed excellent discrimination and calibration. |
| Databáze: | OpenAIRE |
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