The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases - recommendations of the IRDiRC Data Mining and Repurposing Task Force
Autor: | Southall, N.T., Natarajan, M., Lau, L.P.L., Jonker, A.H., Deprez, B., Guilliams, T., Hunter, L., Rademaker, C.M.A., Hivert, V., Ardigo, D., Cavalla, D., Colvis, C., Hettne, K., t'Hoen, P.B., Kant, C., Krischer, J., Marin, F., Quintana, J., Rademaker, C., Reed, J., Southali, N., Tsigkos, S., Thompson, R., IRDiRC Data Min Repurposing Task |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Big Data
0301 basic medicine Biomedical Research Databases Factual Computer science IRDiRC lcsh:Medicine Drug development computer.software_genre Orphan drug 03 medical and health sciences Rare Diseases 0302 clinical medicine Humans Genetics(clinical) Pharmacology (medical) Position Statement Data mining Genetics (clinical) Repurposing Pace Task force lcsh:R Repositioning Drug Repositioning General Medicine Precision medicine 3. Good health Drug repositioning 030104 developmental biology Therapies computer Rare disease Orphan medical product 030217 neurology & neurosurgery |
Zdroj: | Orphanet Journal of Rare Diseases, 14(1). BMC Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-8 (2019) Orphanet Journal of Rare Diseases, 14, 225. BMC Orphanet Journal of Rare Diseases, 14(1). BioMed Central Orphanet Journal of Rare Diseases |
ISSN: | 1750-1172 |
Popis: | The number of available therapies for rare diseases remains low, as fewer than 6% of rare diseases have an approved treatment option. The International Rare Diseases Research Consortium (IRDiRC) set up the multi-stakeholder Data Mining and Repurposing (DMR) Task Force to examine the potential of applying biomedical data mining strategies to identify new opportunities to use existing pharmaceutical compounds in new ways and to accelerate the pace of drug development for rare disease patients. In reviewing past successes of data mining for drug repurposing, and planning for future biomedical research capacity, the DMR Task Force identified four strategic infrastructure investment areas to focus on in order to accelerate rare disease research productivity and drug development: (1) improving the capture and sharing of self-reported patient data, (2) better integration of existing research data, (3) increasing experimental testing capacity, and (4) sharing of rare disease research and development expertise. Additionally, the DMR Task Force also recommended a number of strategies to increase data mining and repurposing opportunities for rare diseases research as well as the development of individualized and precision medicine strategies. |
Databáze: | OpenAIRE |
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