4-tert-octylphenol and 17β-estradiol applied by feeding to flounder Platichthys flesus: induction of vitellogenin and accumulation in tissues
| Autor: | Bodil Korsgaard, Poul Bjerregaard, Louise Leonharder Madsen |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Muscle tissue medicine.medical_specialty Alkylphenol Administration Oral Flounder Aquatic Science Biology Pleuronectidae Oceanography Surface-Active Agents Vitellogenins Vitellogenin chemistry.chemical_compound Phenols Internal medicine medicine Animals Tissue Distribution Muscle Skeletal Estradiol General Medicine biology.organism_classification Animal Feed Pollution Platichthys Diet medicine.anatomical_structure Endocrinology Liver Endocrine disruptor chemistry biology.protein Xenobiotic |
| Zdroj: | University of Southern Denmark |
| ISSN: | 0141-1136 |
| DOI: | 10.1016/s0141-1136(02)00111-3 |
| Popis: | In order to simulate a possible natural administration route of xenoestrogens male flounder Platichthys flesus were exposed via the diet to the alkylphenol 4- tert -octylphenol. Treatment with 4- tert -octylphenol (10, 50 and 100 mg OP kg −1 BW) or 17β-estradiol (0.05 mg kg −1 BW) every second day during a period of 11 days resulted in a significant increase in plasma vitellogenin (Vtg) concentrations. The induction of Vtg was greatest in the fish receiving 50 mg OP kg −1 BW. A significant accumulation of 4- tert -octylphenol was found in liver and muscle tissue of the OP treated groups. The tissue concentrations of 4- tert -octylphenol and the plasma vitellogenin concentration were positively correlated. The results show that 4- tert -octylphenol accumulates in liver and muscles of flounder P. flesus , and exerts estrogenic effects such as vitellogenin induction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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