Opioid-Induced Constipation in Oncological Patients: New Strategies of Management
| Autor: | T. Sauri, Eduardo Pujol, Jose Gómez, Ricard Mesía, Juan Antonio Virizuela Echaburu, Gloria Serrano |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Constipation Pain Palliative and Supportive Care (MP Davis Section Editor) Naloxegol law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Neoplasms Naloxone medicine Humans Pain Management Pharmacology (medical) Intensive care medicine Cancer business.industry Disease Management Cancer Pain Opioid-induced constipation Analgesics Opioid Opioid induced constipation Oncology chemistry Laxatives Opioid analgesics 030220 oncology & carcinogenesis Treatment strategy 030211 gastroenterology & hepatology medicine.symptom business Opioid-Induced Constipation medicine.drug |
| Zdroj: | Zaguán. Repositorio Digital de la Universidad de Zaragoza instname Current Treatment Options in Oncology |
| Popis: | Opinion statementCancer-associated pain has traditionally been treated with opioid analgesics, often in escalating doses. Opioid-induced constipation (OIC) is a common problem associated with chronic use of opioid analgesics. Typical treatment strategies to alleviate constipation are based on dietary changes, exercise, and laxatives. However, laxatives have a nonspecific action and do not target underlying mechanisms of OIC. This article will review prevalent, clinical presentation and recommendations for the treatment of OIC. An independent literature search was carried out by the authors. We reviewed the literature for randomized controlled trials that studied the efficacy of laxatives, naloxone, and naloxegol in treating OIC. Newer strategies addressing the causal pathophysiology of OIC are needed for a more effective assessment and management of OIC. Finally, traditional recommended therapies are appraised and compared with the latest pharmacological developments. Future research should address whether naloxegol is more efficacious by its comparison directly with first-line treatments, including laxatives. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|