Protective Effects of Huangqi Shengmai Yin on Type 1 Diabetes-Induced Cardiomyopathy by Improving Myocardial Lipid Metabolism
| Autor: | Dong Han, Na Li, Chunqiu Fang, Xiao Bo Qu, Xin Sui, Jianheng Pan, Zhanhong Cao, Xiaowei Huang |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Article Subject endocrine system diseases Heart disease Cardiomyopathy 030204 cardiovascular system & hematology Other systems of medicine 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Diabetic cardiomyopathy medicine 030304 developmental biology 0303 health sciences Type 1 diabetes business.industry nutritional and metabolic diseases Lipid metabolism medicine.disease Streptozotocin Endocrinology Complementary and alternative medicine Electrical conduction system of the heart business RZ201-999 Research Article medicine.drug |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021) Evidence-based Complementary and Alternative Medicine : eCAM |
| ISSN: | 1741-4288 1741-427X |
| Popis: | Diabetic cardiomyopathy (DCM) is one of the many complications of diabetes. DCM leads to cardiac insufficiency and myocardial remodeling and is the main cause of death in diabetic patients. Abnormal lipid metabolism plays an important role in the occurrence and development of DCM. Huangqi Shengmai Yin (HSY) has previously been shown to alleviate signs of heart disease. Here, we investigated whether HSY could improve cardiomyopathy caused by type 1 diabetes mellitus (T1DM) and improve abnormal lipid metabolism in the diabetic heart. Streptozotocin (STZ) was used to establish the T1DM mouse model, and T1DM mice were subsequently treated with HSY for eight weeks. The changes in the cardiac conduction system, histopathology, blood myocardial injury indices, and lipid content and expression of proteins related to lipid metabolism were evaluated. Our results showed that HSY could improve electrocardiogram; decrease the serum levels of CK-MB, LDH, and BNP; alleviate histopathological changes in cardiac tissue; and decrease myocardial lipid content in T1DM mice. These results indicate that HSY has a protective effect against T1DM-induced myocardial injury in mice and that this effect may be related to the improvement in myocardial lipid metabolism. |
| Databáze: | OpenAIRE |
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