The feasibility of procalcitonin and CPIS score to reduce inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients: A pilot study

Autor:	Ornnicha Sathitakorn, Kittiya Jantarathaneewat, David J. Weber, David K. Warren, Sira Nanthapisal, Sasinuch Rutjanawech, Piyaporn Apisarnthanarak, Anucha Apisarnthanarak
Rok vydání:	2022
Předmět:	Epidemiology Critical Illness Health Policy Public Health Environmental and Occupational Health Pilot Projects Pneumonia Communicable Diseases Anti-Bacterial Agents COVID-19 Drug Treatment Infectious Diseases Feasibility Studies Humans Procalcitonin Biomarkers
Zdroj:	American Journal of Infection Control. 50:581-584
ISSN:	0196-6553
DOI:	10.1016/j.ajic.2022.01.030
Popis:	Antibiotics have been extensively used in COVID-19 patients without a clear indication. We conducted a study to evaluate the feasibility of procalcitonin along with the "Clinical Pulmonary for Infection Score" (CPIS) as a strategy to reduce inappropriate antibiotic use. Using procalcitonin and CPIS score (PCT-CPIS) successfully reduced inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients (45% vs 100%; P.01). Compared to "non PCT-CPIS" group, "PCT-CPIS" group was associated with a reduction in the incidence of multidrug-resistant organisms and invasive fungal infections (18.3% vs 36.7%; P = .03), shorter antibiotic duration (2 days vs 7 days; P.01) and length of hospital stay (10 days vs 16 days; P.01).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dced37864a9c007bf1aa7630720c25e0 https://doi.org/10.1016/j.ajic.2022.01.030 Zobrazit plný text záznamu Full Text from ScienceDirect