Flow Dynamics in the Aortic Arch and Its Effect on the Arterial Input Function in Cardiac Computed Tomography
| Autor: | Jung Hee Seo, Rajat Mittal, Albert C. Lardo, Parastou Eslami, Marcus Y. Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Aortic arch
medicine.medical_specialty Flow (psychology) Biomedical Engineering Pulsatile flow Technical Brief Hemodynamics 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine medicine.artery medicine cardiovascular diseases 030304 developmental biology Computed tomography angiography 0303 health sciences Aorta medicine.diagnostic_test business.industry Dynamics (mechanics) Descending aorta cardiovascular system Cardiology business |
| Zdroj: | J Biomech Eng |
| ISSN: | 1528-8951 0148-0731 |
| Popis: | The arterial input function (AIF)—time-density curve (TDC) of contrast at the coronary ostia—plays a central role in contrast enhanced computed tomography angiography (CTA). This study employs computational modeling in a patient-specific aorta to investigate mixing and dispersion of contrast in the aortic arch (AA) and to compare the TDCs in the coronary ostium and the descending aorta. Here, we examine the validity of the use of TDC in the descending aorta as a surrogate for the AIF. Computational fluid dynamics (CFD) was used to study hemodynamics and contrast dispersion in a CTA-based patient model of the aorta. Variations in TDC between the aortic root, through the AA and at the descending aorta and the effect of flow patterns on contrast dispersion was studied via postprocessing of the results. Simulations showed complex unsteady patterns of contrast mixing and dispersion in the AA that are driven by the pulsatile flow. However, despite the relatively long intra-aortic distance between the coronary ostia and the descending aorta, the TDCs at these two locations were similar in terms of rise-time and up-slope, and the time lag between the two TDCs was 0.19 s. TDC in the descending aorta is an accurate analog of the AIF. Methods that use quantitative metrics such as rise-time and slope of the AIF to estimate coronary flowrate and myocardial ischemia can continue with the current practice of using the TDC at the descending aorta as a surrogate for the AIF. |
| Databáze: | OpenAIRE |
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