Insulin resistance in transgender individuals correlates with android fat mass
| Autor: | Jeffrey D Zajac, Mathis Grossmann, Gehan Premaratne, Cassandra Spanos, Shalem Leemaqz, Ingrid Bretherton, Ada S Cheung |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Gender dysphoria
Gerontology body composition lcsh:RC648-665 Gender identity business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment transsexualism gender dysphoria medicine.disease lcsh:Diseases of the endocrine glands. Clinical endocrinology Increased risk Insulin resistance insulin resistance Transgender Medicine transgender persons Hormone therapy Android fat distribution gender identity business Cardiovascular outcomes Original Research |
| Zdroj: | Therapeutic Advances in Endocrinology and Metabolism Therapeutic Advances in Endocrinology and Metabolism, Vol 12 (2021) |
| ISSN: | 2042-0196 2042-0188 |
| DOI: | 10.1177/2042018820985681 |
| Popis: | Background: Transgender individuals receiving gender-affirming hormone therapy (GAHT) are at increased risk of adverse cardiovascular outcomes. This may be related to effects on body composition and insulin resistance. Aims: To examine relationships between body fat distribution and insulin resistance in transgender individuals on established GAHT. Methods: Comparisons of body composition (dual energy X-ray absorptiometry) and insulin resistance [Homeostasis Model of Insulin Resistance (HOMA2-IR)] were made between transgender individuals (43 trans men and 41 trans women) on established GAHT (>12 months) and age-matched cisgender controls (30 males and 48 females). Multiple linear regressions were used to examine the relationship between HOMA2-IR and fat mass with gender, adjusting for age and total duration of GAHT and Pearson correlation coefficients are reported. Results: Compared with control cisgender women, trans men had mean difference of +7.8 kg (4.0, 11.5), p 2 = 0.712, p 2 = 0.572, p Conclusion: Android fat more strongly correlates with insulin resistance than gynoid fat in transgender individuals. Higher fat mass and insulin resistance in trans women may predispose to increased cardiovascular risk. Despite adverse fat distribution, insulin resistance was not higher in trans men. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|