Investigating neural circuits of emotion regulation to distinguish euthymic patients with bipolar disorder and major depressive disorder

Autor:	Ana Rita Barreiros, Anthony Harris, Philip Hazell, Sheryl Foster, Kristi Griffiths, Richard A. Bryant, Mayuresh S. Korgaonkar, Wenting Chen, Philip Boyce, Sabina Rai, Gin S Malhi, Isabella A. Breukelaar
Rok vydání:	2021
Předmět:	Bipolar Disorder Emotions Affect (psychology) behavioral disciplines and activities Amygdala Cognitive reappraisal 03 medical and health sciences 0302 clinical medicine medicine Humans Bipolar disorder Reactivity (psychology) Biological Psychiatry Depression (differential diagnoses) Depressive Disorder Major medicine.disease Magnetic Resonance Imaging Cyclothymic Disorder Emotional Regulation 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Mood disorders Major depressive disorder Psychology 030217 neurology & neurosurgery Clinical psychology
Zdroj:	Bipolar Disorders. 23:284-294
ISSN:	1399-5618 1398-5647
DOI:	10.1111/bdi.13042
Popis:	Background Up to 40% of patients with bipolar disorder (BD) are initially diagnosed as having major depressive disorder (MDD), and emotional lability is a key aspect of both sets of mood disorders. However, it remains unknown whether differences in the regulation of emotions through cognitive reappraisal may serve to distinguish BD and MDD. Therefore, we examined this question in euthymic BD and MDD patients. Methods Thirty-eight euthymic BD, 33 euthymic MDD and 37 healthy control (HC) participants, matched for age, gender and depression severity, engaged in an emotion regulation (ER) cognitive reappraisal task during an fMRI scan were examined. Participants either reappraised (Think condition) or passively watched negative (Watch condition) or neutral (Neutral condition) pictures and rated their affect. Activation and connectivity analyses were used to examine group differences in reappraisal (Think vs Watch) and reactivity (Watch vs Neutral) conditions in ER-specific neural circuits. Results Irrespective of group, participants rated most negatively the images during the Watch condition relative to Think and Neutral conditions, and more negatively to Think relative to Neutral. Notably, BD participants exhibited reduced subgenual anterior cingulate activation (sgACC) relative to MDD during reappraisal, but exhibited greater sgACC activation relative to MDD during reactivity, whereas MDD participants elicited greater activation in right amygdala relative to BD during reactivity. We found no group differences in task-related connectivity. Conclusions Euthymic BD and MDD patients engage differential brain regions to process and regulate emotional information. These differences could serve to distinguish the clinical groups and provide novel insights into the underlying pathophysiology of BD.
Databáze:	OpenAIRE
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