Relationship of Urinary cGMP Excretion with Aging and Menopausal Status in a General Population
| Autor: | Hironori Imano, Kazumasa Yamagishi, Tetsuya Ohira, Hiroyasu Iso, Akihiko Kitamura, Renzhe Cui, Takeshi Tanigawa, Masamitsu Konishi, M Kiyama, Takashi Shimamoto |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Cross-sectional study Urinary system Population Vasodilation Excretion chemistry.chemical_compound Japan Internal medicine Internal Medicine medicine Humans education Cyclic GMP Aged Creatinine education.field_of_study business.industry Biochemistry (medical) Radioimmunoassay Middle Aged medicine.disease Menopause Endocrinology chemistry Cardiovascular Diseases Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Atherosclerosis and Thrombosis. 16:457-462 |
| ISSN: | 1880-3873 1340-3478 |
| Popis: | AIM Aging and postmenopausal women are associated with increased risks of cardiovascular disease; however, epidemiological evidence concerning the relationship of aging and the menopause with vascular biological activity is limited. METHODS We investigated the relationship of aging and the menopause with urinary excretion of cyclic guanosine 3',5' monophosphate (cGMP) in 1,541 Japanese men and women aged 40 to 79 years. The 24-hour urinary excretion of cGMP was measured with a (125)I-labeled cGMP radioimmunoassay and was adjusted for urinary creatinine excretion (nmol/mmol creatinine). RESULTS Aging was positively associated with urinary excretion of cGMP for both sexes. Postmenopausal women excreted significantly less urinary cGMP than premenopausal women after adjustment for age and other cardiovascular risk factors: 48.3+/-0.04 nmol/mmol vs. 61.5+/-0.07 nmol/mmol, p=0.006. CONCLUSIONS Our data suggest that cGMP-related vasodilatation is impaired in postmenopausal women. |
| Databáze: | OpenAIRE |
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