In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia
| Autor: | Alexander D. Borowsky, Craig K. Abbey, Jeannie E. Maglione, Simon R. Cherry, Robert D. Cardiff, Jeffrey P. Gregg, Erik T. McGoldrick |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Pathology
medicine.medical_specialty Mammary Neoplasms Animal Mice Breast cancer Mammary Glands Animal In vivo Fluorodeoxyglucose F18 medicine Animals Longitudinal Studies Intraepithelial neoplasia Multidisciplinary Invasive carcinoma medicine.diagnostic_test business.industry Ductal carcinoma Biological Sciences medicine.disease Disease Models Animal Tumor progression Positron emission tomography Disease Progression business Human cancer Tomography Emission-Computed |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 101(31) |
| ISSN: | 0027-8424 |
| Popis: | Imaging mouse models of human cancer promises more effective analysis of tumor progression and reduction of the number of animals needed for statistical power in preclinical therapeutic intervention trials. This study utilizes positron emission tomography imaging of 2-[ 18 F]-fluoro-deoxy- d -glucose to monitor longitudinal development of mammary intraepithelial neoplasia outgrowths in immunocompetent FVB/NJ mice. The mammary intraepithelial neoplasia outgrowth tissues mimic the progression of breast cancer from premalignant ductal carcinoma in situ to invasive carcinoma. Progression of disease is clearly evident in the positron emission tomography images, and tracer uptake correlates with histological evaluation. Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|