Training to improve contrast sensitivity in amblyopia: correction of high-order aberrations
| Autor: | Qian Li, Yifeng Zhou, Meng Liao, Haoxing Zhao, Yun Dai, Longqian Liu, Yudong Zhang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Visual acuity Visual perception Adolescent genetic structures media_common.quotation_subject Visual Acuity Amblyopia Article 050105 experimental psychology Young Adult 03 medical and health sciences 0302 clinical medicine Perceptual learning medicine Humans Learning Contrast (vision) 0501 psychology and cognitive sciences Computer vision Sensitivity (control systems) High order media_common Neuronal Plasticity Multidisciplinary Adult patients business.industry 05 social sciences Age Factors eye diseases Eyeglasses Visual plasticity Visual Perception 030221 ophthalmology & optometry Optometry Artificial intelligence medicine.symptom business Psychology Photic Stimulation |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep35702 |
| Popis: | Perceptual learning is considered a potential treatment for amblyopia even in adult patients who have progressed beyond the critical period of visual development because adult amblyopes retain sufficient visual plasticity. When perceptual learning is performed with the correction of high-order aberrations (HOAs), a greater degree of neural plasticity is present in normal adults and those with highly aberrated keratoconic eyes. Because amblyopic eyes show more severe HOAs than normal eyes, it is interesting to study the effects of HOA-corrected visual perceptual learning in amblyopia. In the present study, we trained twenty-six older child and adult anisometropic amblyopes while their HOAs were corrected using a real-time closed-loop adaptive optics perceptual learning system (AOPL). We found that adaptive optics (AO) correction improved the modulation transfer functions (MTFs) and contrast sensitivity functions (CSFs) of older children and adults with anisometropic amblyopia. When perceptual learning was performed with AO correction of the ocular HOAs, the improvements in visual function were not only demonstrated in the condition with AO correction but were also maintained in the condition without AO correction. Additionally, the learning effect with AO correction was transferred to the untrained visual acuity and fellow eyes in the condition without AO correction. |
| Databáze: | OpenAIRE |
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