Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives
| Autor: | Robert C. Reynolds, William J. Suling, Lainne E. Seitz |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pyrazine
Stereochemistry medicine.drug_class Microbial Sensitivity Tests Antimycobacterial Chemical synthesis Mycobacterium tuberculosis chemistry.chemical_compound Structure-Activity Relationship Quinoxaline Pyrazinoic acid Quinoxalines Drug Discovery medicine Antibacterial agent biology bacterial infections and mycoses biology.organism_classification Pyrazinamide Anti-Bacterial Agents chemistry Pyrazines Molecular Medicine Mycobacterium Mycobacterium avium |
| Zdroj: | Journal of medicinal chemistry. 45(25) |
| ISSN: | 0022-2623 |
| Popis: | A series of pyrazine and quinoxaline derivatives have been synthesized, and their activity against M. tuberculosis (Mtb) and Mycobacterium avium (MAC) are reported. The 4-acetoxybenzyl ester of pyrazinoic acid and 4'-acetoxybenzyl 2-quinoxalinecarboxylate showed excellent activity against Mtb (MIC ranges of less than 1-6.25 microg/mL) but only modest activity against MAC (MICs of 4-32 microg/mL). |
| Databáze: | OpenAIRE |
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