Body size in early life and risk of lymphoid malignancies and histological subtypes in adulthood
| Autor: | Yang TO, Cairns BJ, Kroll ME, Reeves GK, Green J, Beral V, for the Million Women Study Collaborators (incl. Canfell K) |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male obesity Cancer Research Birth weight Physiology body mass index lymphoma Childhood obesity 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Birth Weight Body Size Humans 030212 general & internal medicine Child Adiposity Aged Etiology - Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors Proportional hazards model business.industry Confounding Cancer Middle Aged medicine.disease Obesity United Kingdom Leukemia Lymphoid Lymphoma lymphoid malignancies myeloma Oncology 030220 oncology & carcinogenesis Immunology Female business childhood obesity Body mass index Cancer Epidemiology |
| Zdroj: | International Journal of Cancer |
| Popis: | Risk of adult lymphoid malignancy is associated with recent adiposity. Some have reported apparent associations with adiposity in childhood or early adulthood, but whether these associations are independent of recent adiposity is unknown. Birth weight, body size at age 10 years, clothes size at age 20 years, and recent body mass index (BMI) were recorded in 745,273 UK women, mean age 60.1 (SD 4.9) at baseline, without prior cancer. They were followed for 11 years, during which time 5,765 lymphoid malignancies occurred. Using Cox regression, a higher risk of lymphoid malignancy was strongly associated with higher recent BMI (RR=1.33, 95%CI 1.17‐1.51, for BMI 35+ vs What's new? Previous research has found a link between obesity and adult lymphoid malignancy risk. In this paper, the researchers report on the relative importance of body size not only at the time of diagnosis, but also at birth, childhood, and age 20. They collected data from more than 750,000 women followed up for a period of 11 years. They showed that BMI at the time of diagnosis was the strongest determinant of risk. Being overweight at age 20 also conferred a small additional risk of lymphoid malignancy. There was comparably little evidence to support an additional role of body size at birth or childhood. |
| Databáze: | OpenAIRE |
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