Evaluation of the genetic parameters for 10 common and five new ESS core autosomal STR loci in seven major geographic regions and the largest metropolitan province of Turkey
Autor: | Cemal Gurkan, Huseyin Sevay, Ramazan Emre, Kemal Murat Canturk |
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Rok vydání: | 2016 |
Předmět: |
Male
0301 basic medicine Aging Turkey Physiology Epidemiology Population Population genetics Context (language use) 03 medical and health sciences 0302 clinical medicine Gene Frequency Genetics Humans 030216 legal & forensic medicine education Allele frequency education.field_of_study Polymorphism Genetic Public Health Environmental and Occupational Health Metropolitan area 030104 developmental biology Geography Geographic regions Str loci Microsatellite Female Microsatellite Repeats Demography |
Zdroj: | Annals of Human Biology. 44:149-163 |
ISSN: | 1464-5033 0301-4460 |
Popis: | Situated at the crossroads of Asia, Middle East and Europe, Turkey has an ethnically diverse population of over 78 milllion people.To investigate the population genetics and potential differences in the autosomal short tandem repeat (STR) polymorphisms across all the major geographic regions and largest metropolitan province of Turkey within the context of the Near Eastern/European genetic landscape.Samples from a total of 5299 unrelated individuals were analysed at 10 common [D2S1338, D3S1358, D8S1179, D16S539, D18S51, D19S433, D21S11, FGA, TH01, vWA] and five new European Standard Set (ESS) core autosomal STR loci [D1S1656, D2S441, D10S1248, D12S391, D22S1045].Allele frequencies, statistical parameters of forensic interest and population differentiation tests were calculated for nine population datasets corresponding to the seven major geographic regions, the largest metropolitan province, and a combined dataset for the entire country. Cumulative results confirmed the presence of significant differences among these nine autosomal datasets themselves and with those from the nearby populations, therefore justifying the differential use of these separate datasets on a case-by-case basis in forensic investigations.This collection of autosomal STR population datasets comprises the largest and most comprehensive of its kind from Turkey so far. |
Databáze: | OpenAIRE |
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