Anti-Proliferative Effect of Allium senescens L. Extract in Human T-Cell Acute Lymphocytic Leukemia Cells

Autor: Sang Woo Lee, Bazarragchaa Badamtsetseg, Jiyeon Kim, Soon Ae Kim, Dae Han Lee
Jazyk: angličtina
Rok vydání: 2020
Předmět:
axitinib
Pharmaceutical Science
Allium senescens
Pharmacology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Peripheral blood mononuclear cell
Jurkat cells
p38 Mitogen-Activated Protein Kinases
Article
Analytical Chemistry
Allium
lcsh:QD241-441
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
lcsh:Organic chemistry
Drug Discovery
medicine
Humans
Physical and Theoretical Chemistry
Phosphorylation
Cytotoxicity
030304 developmental biology
Cell Proliferation
Inflammation
0303 health sciences
biology
Chemistry
Cell growth
Plant Extracts
Organic Chemistry
NF-kappa B
apoptosis
leukemia
biology.organism_classification
medicine.disease
Allium senescens L
Leukemia
Chemistry (miscellaneous)
Apoptosis
030220 oncology & carcinogenesis
Phorbol
Leukocytes
Mononuclear
Molecular Medicine
Interleukin-2
dovitinib
T-ALL
Signal Transduction
Zdroj: Molecules
Volume 26
Issue 1
Molecules, Vol 26, Iss 35, p 35 (2021)
ISSN: 1420-3049
DOI: 10.3390/molecules26010035
Popis: Allium species are well known plants distributed throughout the world, and they contain various bioactive components with different biological activities including anti-cancer effects. In this study, we investigated the inhibitory effect of Allium senescens L. (A.S.) extract on cell survival and IL-2-mediated inflammation in human T cell acute lymphocytic leukemia (T-ALL) Jurkat cells. Our results showed that A.S. extract induced caspase-dependent apoptosis of Jurkat cells with no significant cytotoxicity in the normal peripheral blood mononuclear cells. A.S. extract induced ROS generation through the activation of MAPK p38 phosphorylation. It also inhibited IL-2 mRNA expression and NF-&kappa
B signaling mediated by phorbol 12-myristate 13-acetate, and phytohemagglutinin. Combined treatment with A.S. extract and axitinib/dovitinib exerted enhanced inhibitory effects on T-ALL cell growth and IL-2 production. These results provide novel information on the potential use of A.S. extract as a therapeutic herbal agent for the treatment and prevention of T-ALL.
Databáze: OpenAIRE
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