Macroperiodic Oscillations Are Associated With Seizures Following Acquired Brain Injury in Young Children
| Autor: | Jennifer L Griffith, Joseph Reznikov, ShiNung Ching, Kristin P. Guilliams, Michael J. Morrissey, Michael M. Binkley, Réjean M. Guerriero, Maren Loe, Stuart R. Tomko, Alex Ganniger, Robert Rudock, Sina Khanmohammadi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Physiology Traumatic brain injury Population Electroencephalography Intensive Care Units Pediatric Article law.invention law Seizures Physiology (medical) medicine Humans education Child Acquired brain injury Pediatric intensive care unit education.field_of_study medicine.diagnostic_test Critically ill business.industry Reproducibility of Results medicine.disease Intensive care unit Neurology Child Preschool Brain Injuries Neurology (clinical) business Eeg monitoring |
| Zdroj: | J Clin Neurophysiol |
| Popis: | PURPOSE: Seizures occur in 10% to 40% of critically ill children. We describe a phenomenon seen on color density spectral array but not raw EEG associated with seizures and acquired brain injury in pediatric patients. METHODS: We reviewed EEGs of 541 children admitted to an intensive care unit between October 2015 and August 2018. We identified 38 children (7%) with a periodic pattern on color density spectral array that oscillates every 2 to 5 minutes and was not apparent on the raw EEG tracing, termed macroperiodic oscillations (MOs). Internal validity measures and interrater agreement were assessed. We compared demographic and clinical data between those with and without MOs. RESULTS: Interrater reliability yielded a strong agreement for MOs identification (kappa: 0.778 [0.542–1.000]; P < 0.0001). There was a 76% overlap in the start and stop times of MOs among reviewers. All patients with MOs had seizures as opposed to 22.5% of the general intensive care unit monitoring population (P < 0.0001). Macroperiodic oscillations occurred before or in the midst of recurrent seizures. Patients with MOs were younger (median of 8 vs. 208 days; P < 0.001), with indications for EEG monitoring more likely to be clinical seizures (42 vs. 16%; P < 0.001) or traumatic brain injury (16 vs. 5%, P < 0.01) and had fewer premorbid neurologic conditions (10.5 vs. 33%; P < 0.01). CONCLUSIONS: Macroperiodic oscillations are a slow periodic pattern occurring over a longer time scale than periodic discharges in pediatric intensive care unit patients. This pattern is associated with seizures in young patients with acquired brain injuries. |
| Databáze: | OpenAIRE |
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