Cumulative disease activity predicts incidental hearing impairment in patients with rheumatoid arthritis (RA)
| Autor: | Irazú Contreras-Yáñez, Paula Rivera-Hoyos, Jaqueline Ramírez-Anguiano, Virginia Pascual-Ramos, Lorena Enríquez |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Hearing loss Severity of Illness Index Arthritis Rheumatoid Rheumatology Internal medicine medicine Humans Hearing Loss medicine.diagnostic_test business.industry General Medicine Odds ratio Middle Aged medicine.disease Confidence interval Surgery Hearing level Rheumatoid arthritis Concomitant Antirheumatic Agents Audiometry Pure-Tone Female Pure tone audiometry medicine.symptom business |
| Zdroj: | Clinical rheumatology. 33(3) |
| ISSN: | 1434-9949 |
| Popis: | We previously reported that 24 % of 113 rheumatoid arthritis (RA) patients had hearing impairment (HI). We investigated if disease activity was a predictor of incidental HI. One hundred and four patients completed three consecutive 6 months-apart rheumatic evaluations and concomitant audiometric evaluations which included at least an interview, an otoscopic evaluation, and a pure tone audiometry. HI was defined if the average thresholds for at least one of low-, mid-, or high-frequency ranges were ≥25 decibels (dB) hearing level in one or both ears. Appropriated statistics was used. Internal review board approval was obtained. Patients were most frequently middle-aged (43.4 ± 13.3 years), female (89.4 %), and had median disease duration of 5 years and low disease activity. All were receiving RA treatment. At inclusion, 24 patients had HI which was sensorineural in 91.7% of them. Among the 80 patients without HI at baseline, 10 (12.5 %) developed incidental HI, and they had more disease activity either at baseline ([median, range] disease activity score-28 joints evaluated-C-reactive protein [DAS28-CRP], 3.9 [1.6–7.3] vs. 2.1 [1–8.7], p = 0.006) or cumulative previous incidental HI (3.4 [1.8–4.8] vs. 2 [1–6.2], p = 0.007) and were more frequently on combined methotrexate and sulfasalazine (20 vs. 1.4 %, p = 0.05) than their counterparts. In the adjusted Cox proportional model, cumulative DAS28-CRP was the only variable to predict incidental HI (odds ratio, 1.8; 95 % confidence interval, 1.1–2.7; p = 0.01). Almost 13 % of RA patients with short disease duration and low disease activity developed incidental HI during 1 year. Cumulative disease activity predicted incidental HI. |
| Databáze: | OpenAIRE |
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