Serum levels of perfluorooctanoic acid and perfluorooctane sulfonic acid in pregnant women: Maternal predictors and associations with birth outcomes in the PIPA Project
| Autor: | Aline de Souza Espindola Santos, Armando Meyer, Carmen Ildes Rodrigues Fróes Asmus, Vanessa Emídio Dabkiewicz, Volney de Magalhães Câmara |
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| Rok vydání: | 2021 |
| Předmět: |
Passive smoking
Pilot Projects medicine.disease_cause Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Environmental health medicine Perfluorooctane sulfonic acid Animals Humans Child Fluorocarbons 030219 obstetrics & reproductive medicine Childhood development business.industry Infant Newborn Obstetrics and Gynecology Environmental exposure medicine.disease Perfluorooctane Cross-Sectional Studies chemistry Alkanesulfonic Acids 030220 oncology & carcinogenesis Perfluorooctanoic acid Female Pregnant Women Caprylates business Birth cohort |
| Zdroj: | The journal of obstetrics and gynaecology researchReferences. 47(9) |
| ISSN: | 1447-0756 |
| Popis: | Aim Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent pollutants associated with adverse birth outcomes. This study aimed to identify predictors of blood PFOA and PFOS concentrations in pregnant women and to estimate their associations with birth outcomes in Brazil. Methods We conducted a cross-sectional study with 139 pregnant women enrolled in the pilot study of the Rio Birth Cohort Study on Environmental Exposure and Childhood Development (PIPA Project). Multiple linear regression was used to estimate associations between PFOA and PFOS with maternal predictors and birth outcomes. Results Higher levels of PFOA were observed in women aged 16-19 and 20-39 years, while fish consumption from 0.6 to 2.0 times per week was associated with lower levels of the substance. PFOS levels were higher in women living in houses with up to four rooms but lower in those who reported passive exposure to smoking. Increased newborn length and head circumference were also associated with higher maternal levels of PFOA. Conclusions In our study, age, fish consumption, passive smoking, and the number of rooms in the house were predictors of maternal PFAS levels. However, we did not observe significant associations between maternal plasma PFAS concentrations and birth outcomes. |
| Databáze: | OpenAIRE |
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