Atypical Porcine Pestivirus Circulation and Molecular Evolution within an Affected Swine Herd
| Autor: | Lia van der Hoek, Robin van den Braak, Alba Folgueiras-González, Ad de Groof, Bartjan Simmelink, Martin Deijs |
|---|---|
| Přispěvatelé: | Medical Microbiology and Infection Prevention, AII - Infectious diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
animal diseases 030106 microbiology congenital tremor lcsh:QR1-502 Genome Viral Article lcsh:Microbiology Virus Disease Outbreaks Evolution Molecular viral persistence Viral Proteins 03 medical and health sciences Negative selection Immune system Molecular evolution Virology Tremor Genotype Animals asymptomatic Selection Genetic Phylogeny Retrospective Studies Swine Diseases 2. Zero hunger pestivirus biology phylogenetic analysis Pestivirus Pestivirus Infections Genetic Variation RNA virus swine genomic sequence biology.organism_classification atypical porcine pestivirus (APPV) 030104 developmental biology Infectious Diseases Animals Newborn Herd purifying selection |
| Zdroj: | Viruses Volume 12 Issue 10 Viruses, 12(10):1080. Multidisciplinary Digital Publishing Institute (MDPI) Viruses, Vol 12, Iss 1080, p 1080 (2020) |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v12101080 |
| Popis: | Atypical porcine pestivirus (APPV) is a single-stranded RNA virus from the family Flaviviridae, which is linked to congenital tremor (CT) type A-II in newborn piglets. Here, we retrospectively investigated the molecular evolution of APPV on an affected herd between 2013 and 2019. Monitoring was done at regular intervals, and the same genotype of APPV was found during the entire study period, suggesting no introductions from outside the farm. The nucleotide substitutions over time did not show substantial amino acid variation in the structural glycoproteins. Furthermore, the evolution of the virus showed mainly purifying selection, and no positive selection. The limited pressure on the virus to change at immune-dominant regions suggested that the immune pressure at the farm might be low. In conclusion, farms can have circulation of APPV for years, and massive testing and removal of infected animals are not sufficient to clear the virus from affected farms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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