Lymphocyte-myelin sheath interactions in acute experimental allergic encephalomyelitis
| Autor: | Jonathon D. Sedgwick, William F. Blakemore, B.A. Summers |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Male
Pathology medicine.medical_specialty Demyelinating disease Encephalomyelitis Autoimmune Experimental Encephalomyelitis Lymphocyte Immunology Central nervous system Clinical Neurology Inflammation Cell Communication Biology Article Myelin Immune system medicine Immunology and Allergy Animals Lymphocytes Myelin Sheath Autoimmune disease Cell Nucleus Experimental allergic encephalomyelitis Immunization Passive Myelin Basic Protein Lymphocyte-myelin sheath interaction medicine.disease Rats medicine.anatomical_structure Neurology Spinal Cord Rats Inbred Lew Lymphocyte Transfusion Acute Disease Neurology (clinical) medicine.symptom |
| Zdroj: | Journal of Neuroimmunology |
| ISSN: | 1872-8421 0165-5728 |
| Popis: | Using a passively transferred acute model of experimental allergic encephalomyelitis (EAE) in the rat, inflammatory central nervous system (CNS) lesions were shown to develop rapidly, peak and then resolve. An unusual feature of the lesions in the CNS was the presence of pyknotic cells within myelin sheaths. A sequence of observations indicated that such cells were lymphocytes which had insinuated themselves into the myelin sheath by passage along the interperiod line. The presence of lymphocytes within myelin sheaths, a process which did not lead to demyelination, was considered to represent a change which reflects the specificity of the immune response in this disease. The detection of this change in other CNS autoimmune diseases, notably those associated with virus infections, may be important as an indicator of pathogenetically relevant lymphocyte-myelin interactions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect