New N-substituted hydrazones, derivatives of uridyl aldehyde

Autor:	Tadeusz Bieg, Katarzyna Kral, Agnieszka Kudelko, Aleksandra Dąbrowska, Anna Barabaś, Ilona Wandzik
Rok vydání:	2017
Předmět:	Magnetic Resonance Spectroscopy Stereochemistry Hydrazone Ligands 010402 general chemistry 01 natural sciences Biochemistry Aldehyde Medicinal chemistry chemistry.chemical_compound Isomerism Ribose Genetics Moiety Chelation Protecting group Uridine Chelating Agents chemistry.chemical_classification Aldehydes Manganese 010405 organic chemistry Chemistry Hydrazones General Medicine Nuclear magnetic resonance spectroscopy Tautomer 0104 chemical sciences Molecular Medicine
Zdroj:	Nucleosides, Nucleotides & Nucleic Acids. 36:159-169
ISSN:	1532-2335 1525-7770
Popis:	N-substituted isomeric hydrazones of uridyl aldehyde have been synthesized. The occurrence of the dominant E isomers with respect to the azomethine group was confirmed by means of NMR spectroscopy. Synthesized hydrazones feature an acetonide moiety as a protection of two hydroxyl groups on the ribose part. The attempt to remove the protecting group resulted in an azo-hydrazone tautomeric mixture. The described compounds may be valuable chiral ligands for metal chelation. Assessment of manganese(II) ion affinity to one selected hydrazone was performed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc18fa6ddd8cf7d65d2e8f55e4be964a https://doi.org/10.1080/15257770.2016.1231321 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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