Hypergranular precursor B-cell acute lymphoblastic leukemia in a 16-year-old boy
| Autor: | Prashant Tembhare, Badrinath Yajamanam, Kunal Sehgal, Ashok Kumar, P.G. Subramanian, Sumeet Gujral |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Microbiology (medical)
Male Pathology medicine.medical_specialty Adolescent Acid Phosphatase lcsh:QR1-502 CD34 Cytoplasmic Granules lcsh:Microbiology CD19 Pathology and Forensic Medicine Immunophenotyping immunophenotyping Antigens CD hemic and lymphatic diseases lcsh:Pathology medicine Humans Acute lukemia Peroxidase Acute leukemia biology CD117 business.industry Precursor Cells B-Lymphoid Myeloid leukemia General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma Myeloperoxidase Immunology biology.protein hypergranular blast Antibody business lcsh:RB1-214 |
| Zdroj: | Indian Journal of Pathology and Microbiology, Vol 52, Iss 3, Pp 421-423 (2009) |
| ISSN: | 0974-5130 |
| Popis: | Presence of cytoplasmic granules in the blasts is a well known feature of myeloid leukemia. ALL presenting with the numerous cytoplasmic granules in blasts is a rarity and may be misdiagnosed as acute myeloid leukemia. We describe a rare case of hypergranular precursor B-cell acute lymphoblastic leukemia (ALL) in an adolescent male expressing CD10, CD19, CytoCD22, CD34, as well as CD13 and CD117. The blasts were cytochemically negative for myeloperoxidase (MPO), and acid phosphatase (ACP) but were positive for non-specific esterase (NSE). In centers where immunophenotypic panel is usually decided on the basis of morphology with limited antibodies may result in an erroneous typing of such rare diseases. Hence it is important to be aware of this rare entity and to confirm the lineage of acute leukemia by using a comprehensive panel of antibodies for immunophenotypic analysis. |
| Databáze: | OpenAIRE |
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