Differential Expression of Class I Major Histocompatibility Complex Determinants by Lymphoblastic Leukemia- Lymphoma Cell Lines
| Autor: | Shirley D. Rohrer, Joseph H. Coggin, Paul I. Liu, Raymond B. Hester |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Cancer Research
medicine.drug_class Lymphoblastic Leukemia Genes MHC Class I Mice Inbred Strains Biology Monoclonal antibody Major histocompatibility complex Epitopes Mice Antigen Transplantation Immunology Tumor Cells Cultured medicine Animals Differential expression Leukemia Radiation-Induced Mice Inbred BALB C Lymphoma Non-Hodgkin medicine.disease Leukemia Lymphoid Lymphoma On cells Oncology Cell culture Immunology Cancer research biology.protein Neoplasm Transplantation |
| Zdroj: | JNCI Journal of the National Cancer Institute. 82:1209-1214 |
| ISSN: | 1460-2105 0027-8874 |
| Popis: | Two T-cell lines (XR11-4T and XR11-5T), established from radiation-induced, murine lymphoblastic lymphomas, were examined for the expression of class I major histocompatibility complex antigen and tumor induction. These cell lines expressed class I private determinants, H-2.9 and H-2.26, but not the monomorphic determinant defined by monoclonal antibody M1/42. Both cell lines produced tumors in syngeneic and allogeneic hosts. The monomorphic determinant could be demonstrated on both cell lines following growth in allogeneic (BALB/c mice) but not in syngeneic (RFM mice) hosts. The re-expressed determinant present on cells following growth in allogeneic mice was not of host origin. Thus, tumorigenic x irradiation may differentially affect the expression of class I major histocompatibility complex determinants. |
| Databáze: | OpenAIRE |
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