Discovery of Lucensimycins A and B from Streptomyces lucensis MA7349 Using an Antisense Strategy
| Autor: | Kevin M. Byrne, M. Teresa Díez, Joanne Huber, Oscar Salazar, Deborah L. Zink, Olga Genilloud, Sheo B. Singh, Francisca Vicente, Angela Basilio |
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| Rok vydání: | 2006 |
| Předmět: |
DNA
Bacterial Models Molecular Magnetic Resonance Spectroscopy Streptomyces aureus Microbial Sensitivity Tests Computational biology Biochemistry Streptomyces DNA Antisense Mass Spectrometry Bacterial genetics chemistry.chemical_compound Ribosomal protein Streptomyces lucensis Protein biosynthesis Spiro Compounds Physical and Theoretical Chemistry biology Chemistry Organic Chemistry biology.organism_classification Molecular biology Anti-Bacterial Agents Drug Design DNA |
| Zdroj: | Organic Letters. 8:5449-5452 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol062041r |
| Popis: | Inhibition of protein synthesis is one of the validated and highly successful targets for inhibition of bacterial growth; this mechanism is a target of a large number of clinical drugs. Ribosomal protein S4, a primary protein, is a potential target for the discovery of antibacterial agents. We describe, using an antisense-sensitized rpsD Streptomyces aureus strain, the discovery and activity of lucensimycins A and B. [structure: see text]. |
| Databáze: | OpenAIRE |
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