The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study
| Autor: | Jørn Wulff Helge, Nis Stride, Magnus Asping, Tine Lovsø Dohlmann, Flemming Dela, Ditte Søgaard, Steen Larsen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Blood Glucose Male 0301 basic medicine Simvastatin medicine.medical_specialty Statin Ubiquinone medicine.drug_class medicine.medical_treatment Muscle Fibers Skeletal 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound Oxygen Consumption 0302 clinical medicine Double-Blind Method Internal medicine Respiration medicine Humans Insulin Citrate synthase Pharmacology (medical) Pravastatin Pharmacology Coenzyme Q10 biology Cholesterol business.industry General Medicine Middle Aged Mitochondria Muscle 030104 developmental biology Endocrinology chemistry biology.protein Physical therapy Hydroxymethylglutaryl-CoA Reductase Inhibitors business medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 73:679-687 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/s00228-017-2224-4 |
| Popis: | Statins are used to lower cholesterol in plasma and are one of the most used drugs in the world. Many statin users experience muscle pain, but the mechanisms are unknown at the moment. Many studies have hypothesized that mitochondrial function could be involved in these side effects. The aim of the study was to investigate mitochondrial function after 2 weeks of treatment with simvastatin (S; n = 10) or pravastatin (P; n = 10) in healthy middle-aged participants. Mitochondrial respiratory capacity and substrate sensitivity were measured in permeabilized muscle fibers by high-resolution respirometry. Mitochondrial content (citrate synthase (CS) activity), antioxidant content, as well as coenzyme Q10 concentration (Q10) were determined. Fasting plasma glucose and insulin concentrations were measured, and whole body maximal oxygen uptake (VO2max) was determined. No differences were seen in mitochondrial respiratory capacity although a tendency was observed for a reduction when complex IV respiration was analyzed in both S (229 (169; 289 (95% confidence interval)) vs. 179 (146; 211) pmol/s/mg, respectively; P = 0.062) and P (214 (143; 285) vs. 162 (104; 220) pmol/s/mg, respectively; P = 0.053) after treatment. A tendency (1.64 (1.28; 2.00) vs. 1.28 (0.99; 1.58) mM, respectively; P = 0.092) for an increased mitochondrial substrate sensitivity (complex I-linked substrate; glutamate) was seen only in S after treatment. No differences were seen in Q10, CS activity, or antioxidant content after treatment. Fasting glucose and insulin as well as VO2max were not changed after treatment. Two weeks of statin (S or P) treatment have no major effect on mitochondrial function. The tendency for an increased mitochondrial substrate sensitivity after simvastatin treatment could be an early indication of the negative effects linked to statin treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink