Synthesis and preliminary antileukemic studies of cyclic mitoguazone analogues
| Autor: | Izabella Kr żel, Julita Graczyk |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
chemistry.chemical_classification
Chemotherapy Mitoguazone Molecular Structure Pyrimidine Bicyclic molecule Stereochemistry medicine.medical_treatment Pharmaceutical Science Hydrazone Antineoplastic Agents Chemical synthesis Mice chemistry.chemical_compound chemistry Mice Inbred DBA In vivo Drug Discovery medicine Animals Leukemia L1210 Cytotoxicity |
| Zdroj: | Il Farmaco. 53:244-247 |
| ISSN: | 0014-827X |
| DOI: | 10.1016/s0014-827x(98)00011-1 |
| Popis: | Analogues of mitoguazone bearing a terminal amidino group as a part of the seven-membered ring of 1,3-diazepine and six-membered ring of pyrimidine were prepared in order to evaluate in vivo antileukemic action towards L1210 leukemia in mice. Preliminary pharmacological screening showed that the investigated compounds increase the life span (T/C%) of the treated mice in comparison with the untreated animals. The strongest antineoplastic effect was exhibited by compound 8. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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