Evaluation of peripheral blood T lymphocyte surface activation markers and transcription factors in patients with early stage non-small cell lung cancer
| Autor: | Jacek Rutkowski, Kamila Bemben, Aleksandra Rutkowska, Marcin Gruchała, Zbigniew Kmieć, Agnieszka Pliszka, Tomasz Jerzy Ślebioda, Renata Zaucha, Marta Cyman |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male 0301 basic medicine Lung Neoplasms Programmed Cell Death 1 Receptor Immunology CD8-Positive T-Lymphocytes Biology Lymphocyte Activation 03 medical and health sciences 0302 clinical medicine Antigen Antigens CD Carcinoma Non-Small-Cell Lung medicine Humans CTLA-4 Antigen Lymphocyte Count Prospective Studies IL-2 receptor Lung cancer Transcription factor Aged Immunogenicity CD28 Forkhead Transcription Factors T lymphocyte medicine.disease Treatment Outcome 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Female CD8 |
| Zdroj: | Cellular Immunology. 322:26-33 |
| ISSN: | 0008-8749 |
| Popis: | Lung cancer cells harboring multiple mutations as a consequence of long-term damage by different etiologic factors are responsible for high immunogenicity. Immune checkpoint inhibitors significantly improve treatment results in non-small cell lung cancer (NSCLC). Unfortunately, the role of T-lymphocytes in early NSCLC has not been sufficiently elucidated. The aim of this study was to characterize peripheral blood T cells expressing several selected surface antigens (CD4, CD8, CD25, CD28, PD-1, CTLA-4) and transcription factors (T-bet, ROR-yt, Fox-P3, GATA-3) in this patient population. The study group (LC) consisted of 80 treatment-naïve patients with T1/2aN0M0 NSCLC and was compared with 40 cancer-free patients matched for non-oncological diseases and demographic parameters (CG). Significantly higher counts of CTLA-4+cells (in both CD4+and CD8+subtypes), a lower proportion of PD-1 expressing cells and a significantly higher percentage of Fox-P3+CD4+cells were found in the LC group. The high proportion of CD4+PD-1+cells significantly correlated with poor outcomes in LC group, while low CD4/CD8 ratio predicted a better prognosis. Based on our results it seems that NSCLC even at early stages of development initiate changes in the proportions of T cells that may have a significant impact on the clinical outcome. |
| Databáze: | OpenAIRE |
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