Anterior cingulate N-acetylaspartate/creatine ratios during clonidine treatment in a maltreated child with posttraumatic stress disorder
| Autor: | Keith Harenski, Matcheri S. Keshavan, M. D. De Bellis |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Magnetic Resonance Spectroscopy Poison control Creatine Gyrus Cinguli Clonidine Stress Disorders Post-Traumatic chemistry.chemical_compound Internal medicine medicine Humans Pharmacology (medical) Child Abuse Prefrontal cortex Child N-acetylaspartate Aspartic Acid Psychiatry and Mental health Posttraumatic stress chemistry Cingulate region Pediatrics Perinatology and Child Health Cardiology Maltreated child Psychology Adrenergic alpha-Agonists Clinical psychology medicine.drug |
| Zdroj: | Journal of child and adolescent psychopharmacology. 11(3) |
| ISSN: | 1044-5463 |
| Popis: | Posttraumatic stress disorder in maltreated children is associated with dysregulation of biological stress systems, adverse brain development, and neuronal loss in the anterior cingulate region of the medial prefrontal cortex. A maltreated boy with posttraumatic stress disorder was followed prospectively using single voxel proton magnetic resonance spectroscopy measures of anterior cingulate N-acetylaspartate/creatine ratios, a marker of neural integrity. N-acetylaspartate/creatine ratios increased, and sleep measures improved upon symptom remission. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|