Gut cytokines modulate olfaction through metabolic reprogramming of glia
| Autor: | Xiaoyu Tracy Cai, Stephen R. Quake, Yuxin Liang, Jovencio Borneo, Martin Borch Jensen, Pejmun Haghighi, Hongjie Li, Elie Maksoud, Liqun Luo, Heinrich Jasper |
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| Rok vydání: | 2021 |
| Předmět: |
Aging
Metabolic reprogramming Sensory system Olfaction Article Avoidance Learning medicine Animals Drosophila Proteins Lactic Acid Drosophila Janus Kinases Inflammation Neurons Multidisciplinary biology Mechanism (biology) fungi Transporter Lipid Metabolism biology.organism_classification Intestines Smell Survival Rate STAT Transcription Factors Drosophila melanogaster Pectobacterium carotovorum medicine.anatomical_structure Ageing Cytokines Female Antennal lobe Neuroglia Neuroscience Signal Transduction Transcription Factors |
| Zdroj: | Nature |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | Infection-induced aversion against enteropathogens is a conserved sickness behaviour that can promote host survival1,2. The aetiology of this behaviour remains poorly understood, but studies in Drosophila have linked olfactory and gustatory perception to avoidance behaviours against toxic microorganisms3-5. Whether and how enteric infections directly influence sensory perception to induce or modulate such behaviours remains unknown. Here we show that enteropathogen infection in Drosophila can modulate olfaction through metabolic reprogramming of ensheathing glia of the antennal lobe. Infection-induced unpaired cytokine expression in the intestine activates JAK-STAT signalling in ensheathing glia, inducing the expression of glial monocarboxylate transporters and the apolipoprotein glial lazarillo (GLaz), and affecting metabolic coupling of glia and neurons at the antennal lobe. This modulates olfactory discrimination, promotes the avoidance of bacteria-laced food and increases fly survival. Although transient in young flies, gut-induced metabolic reprogramming of ensheathing glia becomes constitutive in old flies owing to age-related intestinal inflammation, which contributes to an age-related decline in olfactory discrimination. Our findings identify adaptive glial metabolic reprogramming by gut-derived cytokines as a mechanism that causes lasting changes in a sensory system in ageing flies. |
| Databáze: | OpenAIRE |
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