Evaluation of DBM/AM composite as a graft substitute for posterolateral lumbar fusion
| Autor: | Jerome Connor, Qing-Qing Qiu, Patricia A. Murphy, Sana C. Roesch, Kimberly Stock, Teri Panzitta, Mei-Shu Shih |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Fusion
Bone Demineralization Technique Bone Transplantation Lumbar Vertebrae Materials science Demineralized bone matrix medicine.medical_treatment Composite number dBm Biomedical Engineering Bone Matrix Rats Radiography Biomaterials Rats Nude Spinal Fusion Spine fusion Lumbar Spinal fusion Bone Substitutes medicine Animals Biomedical engineering |
| Zdroj: | Journal of Biomedical Materials Research Part B: Applied Biomaterials. :239-245 |
| ISSN: | 1552-4981 1552-4973 |
| DOI: | 10.1002/jbm.b.30726 |
| Popis: | Demineralized bone matrix (DBM) has been investigated as a bone graft substitute for spinal fusion with less morbidity. Various carriers have been added to DBM to enhance its handling characteristics. This study investigates the spinal fusion induced by a composite of DBM and acellular dermal matrix (AM) in comparison with autologous bone in an athymic rat spinal fusion model. Single-level intertransverse process fusions were performed in 60 athymic nude rats grafted with 2 mL/kg of DBM/AM composite, AM alone, or autologous bone. Fusion was assessed at 6 weeks by radiography, manual palpation, and histology. At 6 weeks, 70% of the animals from the DBM/AM composite group exhibited complete spine fusion, whereas 35% from the autologous bone group and 20% from AM group showed bridging with some gaps. The DBM/AM composite induced a significantly higher fusion rate than both the autologous bone and AM groups (p < 0.001) in all measured parameters. The current study demonstrated that using DBM/AM composite can have more robust fusion than autologous bone at 6 weeks in an athymic rat spinal fusion model. |
| Databáze: | OpenAIRE |
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