Altered Ca Homeostasis and Ca Alternans in Left Atrial Myocytes of Spontaneously Hypertensive Rats
| Autor: | Jens Kockskämper, Yulia Nikonova, Judit Preisenberger, Johannes Heß, Cornelia F. Pluteanu, Jelena Plackic |
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| Rok vydání: | 2014 |
| Předmět: |
Tachycardia
0303 health sciences medicine.medical_specialty Sarcolemma Chemistry Calcium channel Biophysics Alpha (ethology) Stimulation Atrial fibrillation medicine.disease Left ventricular hypertrophy 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine cardiovascular system medicine Myocyte cardiovascular diseases medicine.symptom 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Biophysical Journal. 106:729a |
| ISSN: | 0006-3495 |
| Popis: | Chronic hypertension can cause atrial fibrillation. The cellular mechanisms responsible for hypertension-induced atrial tachyarrhythmias, however, are unknown. Here we tested the hypothesis that, in spontaneously hypertensive rats (SHR), altered atrial Ca homeostasis may induce atrial tachyarrhythmias.At 6-8 months of age, SHR had significantly increased systolic blood pressure (185±6 mmHg, N=18; vs WKY: 129±4 mmHg, N=16, P |
| Databáze: | OpenAIRE |
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