MOYAMOYA DISEASE IS ASSOCIATED WITH ENDOTHELIAL ACTIVITY DETECTED BY ANTI-NESTIN ANTIBODY
| Autor: | Tomáš Hrbáč, Romuald Curik, Zdenek Kolar, Jana Dvorackova, Václav Procházka, Jana Chmelová, Pavel Sirucek, Otakar Kraft |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Endothelium Cerebral arteries Nerve Tissue Proteins General Biochemistry Genetics and Molecular Biology Nestin Endothelial activation Intermediate Filament Proteins medicine.artery medicine Humans Moyamoya disease medicine.diagnostic_test Vascular Endothelial Growth Factors business.industry Anatomy Internal elastic lamina medicine.disease Immunohistochemistry Radiography Carotid Arteries Receptors Vascular Endothelial Growth Factor medicine.anatomical_structure Angiography cardiovascular system Female Endothelium Vascular Moyamoya Disease Internal carotid artery business |
| Zdroj: | Scopus-Elsevier ResearcherID |
| ISSN: | 1804-7521 1213-8118 |
| DOI: | 10.5507/bp.2010.024 |
| Popis: | Aim. To describe the case history and new histopathological findings of a young woman suffering from moyamoya disease. Methods. The patient underwent brain computed tomography, magnetic resonance imaging and brain angiography. Vessel samples of a. temporalis superficialis were processed by standard histopathological and immunohistochemical methods by analysis of VEGF, VEGFR and nestin expression. Results. Brain angiography revealed both internal carotid artery stenoses and stenoses of the anterior cerebral arteries. Stenotic parts of vessels were accompanied by coiled and elongated vessels with a picture of „smoke puffs carried away by breeze“ after contrast medium application. Histological examination showed: obstruction of lumen, fibrocellular intimal thickening, tortuosity and disruption of internal elastic lamina. Imunohistochemistry confirmed a defect of the internal elastic membrane of the muscular arteria and progressive intimal thickening accompanied by abnormal smooth muscle cells and, VEGF/VEGFR expression in intima. Nestin positivity in endothelium of arteria indicated that endothelial cells are activated. Conclusion. We found that the endothelium of affected vessels is nestin positive. This, together with the finding of VEGF/VEGFR expression, might suggest an active angiogenetic process We present a new conception of pathogenesis but further studies with higher number of patients are necessary to elucidate the role of these growth factors in the moyamoya disease. |
| Databáze: | OpenAIRE |
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