ApoA-IV phenotype affects diet-induced plasma LDL cholesterol lowering
| Autor: | Jose M. Ordovas, Pedro Mata, Alice H. Lichtenstein, Ernst J. Schaefer, J T Judd, B Clevidence, Jose Lopez-Miranda |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Calorie Apolipoprotein B Saturated fat Population Cholesterol Dietary chemistry.chemical_compound Sex Factors Dietary Fats Unsaturated Gene Frequency Internal medicine Blood plasma medicine Humans education National Cholesterol Education Program Apolipoproteins A education.field_of_study biology Triglyceride Cholesterol Cholesterol HDL Cholesterol LDL Middle Aged Dietary Fats Phenotype Endocrinology chemistry biology.protein Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine |
| Zdroj: | Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 14:884-891 |
| ISSN: | 1049-8834 |
| DOI: | 10.1161/01.atv.14.6.884 |
| Popis: | The National Cholesterol Education Program (NCEP) recommends that dietary total fat, saturated fat, and cholesterol intake be reduced to < or = 30% of calories, < 10% of calories, and < 300 mg/d, respectively (step 1 diet), in the general population to reduce plasma low-density lipoprotein cholesterol (LDL-C) levels and heart disease risk. We examined the LDL-C-lowering response to such a diet (26% fat, 8% saturated fat, and 201 mg/d cholesterol) compared with an average American diet (39% fat, 15% saturated fat, and 435 mg cholesterol/d) in 153 subjects using diet periods of 4 through 24 weeks for each diet phase. The mean LDL-C reduction was 13% in men (n = 93) and 7% in postmenopausal women (n = 60). The effect of apolipoprotein (apo) A-IV phenotype on responsiveness was examined. LDL-C lowering in men was significantly (P < .005) less (7%) for 17 apoA-IV (1/2) subjects than for 76 apoA-IV (1/1) subjects (16%). In women, 7% lowering was observed in both 12 apoA-IV (1/2) subjects and 48 apoA-IV (1/1) subjects. ApoA-IV phenotype had a significant effect on plasma high-density lipoprotein cholesterol levels during both dietary periods; women carrying the apoA-IV-2 allele had higher levels than those homozygous for the apoA-IV-1 allele. The opposite was true for triglyceride levels, but only during the period when the subjects consumed the high-fat, high-cholesterol diet.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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