Materials
| Autor: | E. Johan Foster, Brody A. Frost, Sandra Camarero-Espinosa |
|---|---|
| Přispěvatelé: | Macromolecules Innovation Institute, Materials Science and Engineering |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
Review Degeneration (medical) lcsh:Technology 0302 clinical medicine Back pain Medicine General Materials Science lcsh:QC120-168.85 0303 health sciences education.field_of_study MECHANICAL-PROPERTIES NUCLEUS PULPOSUS medicine.anatomical_structure degenerative disc disease Spinal fusion tissue engineering INTERVERTEBRAL DISC DEGENERATION medicine.symptom lcsh:TK1-9971 FACET JOINT OSTEOARTHRITIS LOW-BACK-PAIN Total disc replacement medicine.medical_specialty Population Degenerative disc disease 03 medical and health sciences ANNULUS FIBROSUS LUMBAR VERTEBRAE EXTRACELLULAR-MATRIX education lcsh:Microscopy 030304 developmental biology CERVICAL-SPINE herniated disc lcsh:QH201-278.5 business.industry lcsh:T Intervertebral disc Spinal cord medicine.disease spinal anatomy Surgery lcsh:TA1-2040 spinal fusion intervertebral disc lcsh:Descriptive and experimental mechanics total disc replacement lcsh:Electrical engineering. Electronics. Nuclear engineering VERTEBRAL END-PLATE business lcsh:Engineering (General). Civil engineering (General) 030217 neurology & neurosurgery |
| Zdroj: | Materials, Vol 12, Iss 2, p 253 (2019) Materials |
| ISSN: | 1996-1944 |
| Popis: | Disc degeneration affects 12% to 35% of a given population, based on genetics, age, gender, and other environmental factors, and usually occurs in the lumbar spine due to heavier loads and more strenuous motions. Degeneration of the extracellular matrix (ECM) within reduces mechanical integrity, shock absorption, and swelling capabilities of the intervertebral disc. When severe enough, the disc can bulge and eventually herniate, leading to pressure build up on the spinal cord. This can cause immense lower back pain in individuals, leading to total medical costs exceeding $100 billion. Current treatment options include both invasive and noninvasive methods, with spinal fusion surgery and total disc replacement (TDR) being the most common invasive procedures. Although these treatments cause pain relief for the majority of patients, multiple challenges arise for each. Therefore, newer tissue engineering methods are being researched to solve the ever-growing problem. This review spans the anatomy of the spine, with an emphasis on the functions and biological aspects of the intervertebral discs, as well as the problems, associated solutions, and future research in the field. Published version |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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