Understanding DNA replication by the bacteriophage T4 replisome
| Autor: | Michelle M. Spiering, Stephen J. Benkovic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
DNA Replication Models Molecular Semiconservative replication DNA polymerase Eukaryotic DNA replication Computational biology DNA-Directed DNA Polymerase Pre-replication complex Biochemistry 03 medical and health sciences Viral Proteins Control of chromosome duplication Species Specificity Multienzyme Complexes Bacteriophage T7 Escherichia coli Bacteriophage T4 Carbon-Nitrogen Ligases Molecular Biology biology Escherichia coli Proteins DNA replication Minireviews Cell Biology 030104 developmental biology biology.protein Replisome Primase Protein Multimerization |
| Popis: | The T4 replisome has provided a unique opportunity to investigate the intricacies of DNA replication. We present a comprehensive review of this system focusing on the following: its 8-protein composition, their individual and synergistic activities, and assembly in vitro and in vivo into a replisome capable of coordinated leading/lagging strand DNA synthesis. We conclude with a brief comparison with other replisomes with emphasis on how coordinated DNA replication is achieved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|