Update 1 of: Over One Hundred Peptide-Activated G Protein-Coupled Receptors Recognize Ligands with Turn Structure

Autor:	David P. Fairlie, Gloria Ruiz-Gómez, Bernhard Pfeiffer, Giovanni Abbenante, Joel D. A. Tyndall
Rok vydání:	2010
Předmět:	Chemistry G protein General Chemistry Ligands Protein Structure Secondary Rhodopsin-like receptors Transmembrane protein Protein Structure Tertiary Receptors G-Protein-Coupled Protein structure Biochemistry Heterotrimeric G protein Extracellular Peptides Receptor G protein-coupled receptor
Zdroj:	Chemical Reviews. 110:PR1-PR41
ISSN:	1520-6890 0009-2665
DOI:	10.1021/cr900344w
Popis:	1. GPCRs: Importance and Occurrence G protein-coupled receptors (GPCRs) are seven transmembrane helical bundle proteins (Figure 1) found on the surface of all cells.1–3 They mediate cellular responses to a diverse range of extracellular stimuli, including both endogenous chemical signals and exogenous environmental agents (e.g., light, amino acids, peptides, proteins, small organic molecules such as amines and lipids, nucleosides, nucleotides, metal ions, and pharmaceuticals). Once activated by an extracellular signal, GPCRs activate heterotrimeric G proteins that interact promiscuously with multiple receptors....
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0256a2a84a7aa44bf757396f7b8171 https://doi.org/10.1021/cr900344w Zobrazit plný text záznamu