Itraconazole pulse therapy is effective in the treatment of tinea capitis in children: an open multicentre study
| Autor: | Aditya K. Gupta, Richard C. Summerbell, Charles Lynde, P. Adam, P. De Doncker, S. L. R. Hofstader, Noufal Raboobee, M.E. Alexis |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Antifungal Agents Itraconazole Administration Oral Microsporum gypseum Dermatology Drug Administration Schedule Pharmacotherapy Trichophyton Humans Medicine Child Adverse effect Tinea Capitis Trichophyton tonsurans Mycosis biology business.industry biology.organism_classification medicine.disease Surgery Regimen Child Preschool Female Tinea capitis business Follow-Up Studies medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1046/j.1365-2133.1997.18141912.x |
| Popis: | In an open multicentre study we have demonstrated that itraconazole pulse therapy, 5 mg/kg per day, is effective and safe in the management of tinea capitis in 10 children (seven boys, three girls, mean age: 6.6 years, age range 4-11 years). The causative organisms were Trichophyton tonsurans (six cases), T. violaceum (two cases), T. soudanense (one case) and Microsporum gypseum (one case). Each pulse of drug therapy lasted 1 week with 2 weeks off between consecutive pulses. One, two and three pulses produced complete, clinical and mycological, cure in one, six and three patients, respectively. The children tolerated the treatment well and there were no clinical or laboratory adverse effects. This 1-week pulse therapy regimen resulted in a high degree of compliance. The preliminary results of this study are promising and need to be evaluated in a larger sample of patients. |
| Databáze: | OpenAIRE |
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