Herpes zoster in SLE: prevalence, incidence and risk factors

Autor:	Andrew Kwan, Hanan Al Rayes, Tijana Lazova, Nicole Anderson, Dennisse Bonilla, Jiandong Su, Zahi Touma
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	glucocorticoids Incidence Immunology General Medicine RC581-607 Epidemiology and Outcomes health care Herpes Zoster systemic lupus erythematosus Risk Factors Prevalence Humans Lupus Erythematosus Systemic Immunologic diseases. Allergy outcome assessment
Zdroj:	Lupus Science and Medicine, Vol 9, Iss 1 (2022) Lupus Science & Medicine
ISSN:	2053-8790
Popis:	ObjectivesThis study aimed to evaluate the prevalence and incidence of herpes zoster (HZ) events and describe its associated factors in a study of patients with SLE.Methods491 consecutive SLE participants were screened for HZ events using a patient-reported questionnaire to capture outcomes on pain and other characteristics associated with HZ events. Sociodemographic, clinical and laboratory measures were also analysed, and time-dependent Cox regression survival analyses were performed to investigate factors associated with HZ events.ResultsPrevalence of HZ was 30.5%, incidence was 14.3 cases per 1000 person-years. Lymphopenia and glucocorticoid dosing were significantly associated with HZ events.ConclusionsHZ is highly prevalent in SLE, which may be linked to disease-related and treatment-related effects on cellular immunity. Our results suggest that the presence of certain risk factors may be useful to allow identification of patients at risk of HZ and improve its management in patients with SLE.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf31cce8bb9179f6d15b7fcbae756f6 https://lupus.bmj.com/content/9/1/e000574.full Zobrazit plný text záznamu