Association of polymorphisms in TP53 and the promoter region of IL10 with gastric cancer in a Kazakh population

Autor: Ivan Shtefanov, Gulmira N. Kulmambetova, Meruyert Imanbekova, Abay Makishev, Aisha N. Iskakova, Akbota Aitkulova, Yerlan Ramankulov
Rok vydání: 2020
Předmět:
Male
Genetic analysis
polymorphism
0302 clinical medicine
Risk Factors
Genotype
cytokine
Medicine
TP53
Promoter Regions
Genetic
Aged
80 and over
Genetics
lcsh:R5-920
education.field_of_study
Geography
General Medicine
Middle Aged
Healthy Volunteers
Kazakhstan
Interleukin-10
030220 oncology & carcinogenesis
Cytokines
Regression Analysis
Female
030211 gastroenterology & hepatology
lcsh:Medicine (General)
Adult
Risk
Adolescent
Short Communication
Population
SNP
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
Young Adult
03 medical and health sciences
Stomach Neoplasms
Genetic model
Humans
Genetic Predisposition to Disease
education
Gene
Alleles
Aged
Polymorphism
Genetic
business.industry
Promoter
Haplotypes
Case-Control Studies
Tumor Suppressor Protein p53
Gastric cancer
business
IL10
Zdroj: Bosnian Journal of Basic Medical Sciences
Bosnian Journal of Basic Medical Sciences (2020)
ISSN: 1840-4812
1512-8601
DOI: 10.17305/bjbms.2020.4761
Popis: The emerging evidence indicates that single nucleotide polymorphisms (SNPs) of the TNF, IL10, TP53, and CD14 genes may determine individual susceptibility to gastric cancer. We aimed to investigate the associations for polymorphisms of the TNF, IL10, TP53, and CD14 genes in a population of Kazakhs, to identify potential risk or protective associations of the SNPs with gastric cancer. A case group of 143 patients hospitalized for gastric cancer was enrolled. Controls were 355 volunteers with no history of any cancer and frequency matched with cases by age. Differences in proportions for categorical variables and the assessment of genotypic frequencies conforming to the Hardy–Weinberg equilibrium law were evaluated by the chi-square test. Associations between genetic polymorphisms and the risk of gastric cancer were estimated by regression analysis. For genetic analysis, three genetic models (additive, dominant, and recessive) were used. Four significant associations were found. The SNPs rs1042522 of TP53 and rs1800896 of IL10 were risk factors for gastric cancer by the additive model. Two polymorphisms of IL10 were protective of gastric cancer, namely, rs1800872 by additive model and rs1800871 by recessive model. No significant associations were observed between TNF and CD14 polymorphisms and gastric cancer. The polymorphisms TP53 rs1042522 and IL10 rs1800896 are associated with gastric cancer risk, while the polymorphisms IL10 rs1800872 and rs1800871 are protective of gastric cancer in the population of Kazakhs.
Databáze: OpenAIRE
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