Prognostic significance of peripheral lymphocyte counts and carcinoembryonic antigens in colorectal carcinoma
| Autor: | Unsup Kim, Papatestas Ae, Arthur H. Aufses |
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| Rok vydání: | 1976 |
| Předmět: |
Male
Oncology medicine.medical_specialty Colorectal cancer Lymphocyte Leukocyte Count Carcinoembryonic antigen Antigen Internal medicine Humans Medicine Lymphocytes Inverse correlation Survival rate Aged Retrospective Studies biology Rectal Neoplasms business.industry Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Carcinoembryonic Antigen Peripheral medicine.anatomical_structure Colonic Neoplasms biology.protein Female Surgery business |
| Zdroj: | Journal of Surgical Oncology. 8:257-262 |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/jso.2930080312 |
| Popis: | An association between pretreatment lymphocyte counts and 5-year prognosis was noted in colorectal cancer. Among 188 patients with 5-year follow-up significant difference in survival rates in relation to lymphocyte counts was noted: 61% for patients with counts greater than 2,000/cm, 30% for those with counts less than 1,000/cmm, and 58% for the intermediate group. Similar differences were also noted within groups with Dukes' B and C lesions and in elderly patients. Highly significant differences were noted in women. Those with Dukes' B and C lesions with counts greater than 2,000/cmm had an 81% survival rate, compared to 50% for those with lower counts X2 = 6.81 P LESS THAN 0.01. Women had significantly higher lymphocyte counts and higher survival rates than men. An inverse correlation was noted between pretreatment lymphocytes and simultaneously determined carcinoembryonic antigens. These observations indicate that lymphocyte counts may be of prognostic value in colorectal cancer when used in association with carcinoembryonic antigens. |
| Databáze: | OpenAIRE |
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