Alterations in Hair Follicle Morphology and Hair Shaft Production After Follicular Unit Transplantation
| Autor: | Marcus Maurer, Gerd Lindner, Reza P. Azar, Alexander Thomas |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Time Factors Biopsy Fluorescent Antibody Technique Neovascularization Physiologic Dermatology 030230 surgery Transplantation Autologous Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Hair cycle Follicular phase medicine Humans Hair transplantation Follicular unit transplantation Scalp integumentary system medicine.diagnostic_test business.industry Alopecia General Medicine Hair follicle Transplantation Treatment Outcome medicine.anatomical_structure Microscopy Electron Scanning business Hair Follicle |
| Zdroj: | The American Journal of Dermatopathology. 38:732-738 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/dad.0000000000000526 |
| Popis: | Follicular unit transplantation is the most commonly performed technique in modern restorative hair transplantation surgery. It relies on the acquisition of intact follicular units from microdissected scalp skin strips and their subsequent transplantation into the recipient regions affected by alopecia. Ideally, the translocation of follicular units from the balding-resistant areas of the scalp (usually the occipital region) to the recipient site should not result in any morphological change in the grafts. Nevertheless, the insults associated with surgical intervention present grafted follicles to mechanical and chemical cues differently from those of the physiological steady-state conditions in undamaged skin. This disruption of the normal follicular microenvironment might alter important aspects of hair biology in grafts, for example, hair cycle and pigmentation, and, in turn, could lead to differences in hair appearance, eventually culminating in a diminished esthetical outcome of the surgery. In this study, the authors analyzed native and grafted scalp hair follicles (HFs) from 2 patients who had undergone follicular unit transplantation surgeries formerly. Scanning electron microscopy and light microscopy-based histomorphometry revealed a marked enlargement of follicular structures in the grafts with a concomitant increase in hair shaft diameter. Immunohistological staining confirmed a thickening of the dermal sheath in transplanted HFs that also harbored a denser vascular network. Taken together, these results show that the grafted HFs analyzed were subjected to marked morphological changes during their residence in the recipient site and that this phenomenon is associated with a modulation of follicular vascularization. |
| Databáze: | OpenAIRE |
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