The efficacy of histamine antagonists as antipruritics in experimentally induced pruritus
| Autor: | Ronald Marks, F E Storari, R J Horton, M G Davies |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Chlorpheniramine medicine.drug_class Histamine Antagonists Dermatology Pharmacology Placebo Guanidines chemistry.chemical_compound Double-Blind Method Histamine H2 receptor Papain medicine Humans Cimetidine skin and connective tissue diseases Antipruritic Clinical Trials as Topic business.industry Pruritus Histamine antagonists General Medicine chemistry Drug Therapy Combination Female business Histamine H1 antagonist medicine.drug |
| Zdroj: | Archives of Dermatological Research. 266:117-120 |
| ISSN: | 1432-069X 0340-3696 |
| DOI: | 10.1007/bf00694619 |
| Popis: | 1. The antipruritic ability of histamine (H1 and H2) antagonists alone and in combination in experimentally induced pruritus has been investigated in 12 normal human volunteers. 2. A combination of cimetidine (H2 anatagonist) and chlorpheniramine (H1 antagonist) proved effective in suppressing itch that was artificially induced by the application of papain and histamine. 3. The combination was more effective than chlorpheniramine or cimetidine alone or placebo. 4. The results suggest that both H1 and H2 receptors are involved in the mediation of pruritus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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