Omega-3 fatty acids improve appetite in cancer anorexia, but tumor resecting restores it
| Autor: | Irina V. Romanova, Eduardo J.B. Ramos, Michael M. Meguid, Susumu Suzuki, Carolina G. Goncalves, Chung Chen |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty media_common.quotation_subject Hypothalamus Appetite Down-Regulation Anorexia Eating Orexigenic Internal medicine Neoplasms Fatty Acids Omega-3 medicine Animals Neuropeptide Y Receptor media_common Arc (protein) business.industry Neuropeptide Y receptor Animal Feed Rats Inbred F344 Rats Up-Regulation Endocrinology Receptor Serotonin 5-HT1B Surgery Serotonin medicine.symptom business Hormone medicine.drug |
| Zdroj: | Surgery. 139(2) |
| ISSN: | 0039-6060 |
| Popis: | Tumor growth leads to cancer anorexia that is ameliorated using omega-3 fatty acids (omega-3FA). We hypothesize that omega-3FA modulates up-regulation of hypothalamic orexigenic neuropeptide Y (NPY) and down-regulation of anorexigenic alpha melanocyte-stimulating hormone (alpha-MSH) and serotonin 1B receptors (5-HT(1B)-receptors) in tumor-bearing rats.Twenty-eight tumor-bearing rats were fed either chow (TB-Control) or omega-3FA (TB-omega-3FA). When anorexia developed in TB-Control rats, they and a cohort of TB-omega-pi-3 rats were killed. The rest had their tumor resected (R-Control and R-omega-3FA), and when anorexic TB-Controls normalized their food intake, brains were removed for hypothalamic immunocytochemical study of NPY, alpha-MSH, and 5-HT(1B)-receptor antibodies concentrations. Comparison among slides were assessed by image analysis and analyzed by ANOVA and t test.At anorexia, hypothalamic NPY in arcuate nucleus (ARC) increased by 38% in TB-omega3FA versus TB-Control, whereas alpha-MSH decreased 64% in ARC and 29% in paraventricular nucleus (PVN). Omega-3FA diet in anorexia (TB-omega-3FA vs R-omega-3FA) produced similar qualitative changes of NPY (22% increase) and alpha-MSH (31% decrease) in ARC, with concomitant decrease of 37% in 5-HT(1B)-receptors in PVN, confirming the influence of omega-3FA on the hypothalamic food intake modulators. However, after tumor resection (TB-Control vs R-Control) a 97% increase in NPY and a 62% decrease in alpha-MSH occurred that was significantly greater than in rats fed omega-3FA diet.Tumor resection and omega-3FA modifies hypothalamic food intake activity, up-regulating NPY and down-regulating alpha-MSH and 5-HT(1B)-receptors. Tumor resection in anorexic rats on chow diet restored hypothalamic NPY, alpha-MSH, and food intake quantitatively more than in rats fed omega3FA diet. |
| Databáze: | OpenAIRE |
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